Quem pode ter a doença de Alzheimer?

Em mais de 90% dos casos de Alzheimer não se sabe a causa da doença. Tipicamente esta doença afeta indivíduos com mais de 65 anos¹. Aproximadamente 5% são considerados casos de doença Alzheimer familiar. Os indivíduos começam a manifestar sintomas entre os 30 e 60 anos. Existe duas vezes mais risco de as mulheres terem doença de Alzheimer.²

Referências

1.Alzheimer’s Association. 2015 Alzheimer’s Disease Facts and Figures. Alzheimer’s & Dementia 2015; 11(3):332+.

2.Alzheimer’s Disease International. World Alzheimer Report 2015: The Global Impact of Dementia. Last accessed on 1 July 2016.

3.Querfurth HW and LaFerla FM. Alzheimer’s Disease. N Engl J Med 2010; 362(4):329-44.

4.The Alzheimer’s Society. Normal ageing vs dementia. [Internet; cited 2019 Aug 9]. Available from: https://www.alzheimers.org.uk/about-dementia/symptoms-and-diagnosis/how-dementia-progresses/ normal-ageing-vs-dementia

5.El-Hayek YH, Wiley RE, et al. Tip of the iceberg: assessing the global socioeconomic costs of alzheimer’s disease and related dementias and strategic implications for stakeholders. J Alzheimers Dis. 2019:70:321-339.

6.John G.F.BougheyNeill, R.Graff-Radford, CHAPTER 65 - ALZHEIMER'S DISEASE, Neurology and Clinical Neuroscience 2007, Pages 846-858, https://doi.org/10.1016/B978-0-323-03354-1.50069-9

[Internet; cited 2020] https://www.ninds.nih.gov/Disorders/All-Disorders/Alzheimers-Disease-Information-Page

7.Bekris, L. M., Yu, C. E., Bird, T. D., & Tsuang, D. W. (2010). Genetics of Alzheimer disease. Journal of geriatric psychiatry and neurology, 23(4), 213–227. https://doi.org/10.1177/0891988710383571

8.Podcasy, J. L., & Epperson, C. N. (2016). Considering sex and gender in Alzheimer disease and other dementias. Dialogues in clinical neuroscience, 18(4), 437–446. https://doi.org/10.31887/DCNS.2016.18.4/cepperson

https://www.alz.org/media/Documents/alzheimers-facts-and-figures.pdf

9.Alzheimer’s disease Association - https://www.alz.org/media/documents/alzheimers-stages-early-middle-late-ts.pdf

10.Livingston G et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020 Aug 8;396(10248):413-446. doi: https://doi.org/10.1016/S0140-6736(20)30367-6

https://alzheimerportugal.org/pt/text-0-9-33-21-exames-utilizados-no-diagnostico-de-demencia

11.Vaz M, Silvestre S. Alzheimer's disease: Recent treatment strategies. Eur J Pharmacol. 2020 Sep 15;887:173554. doi: : https://doi.org/10.1016/j.ejphar.2020.173554.